Hydrogen Sulfide → HCID 178491226, 화합물

HRID 490092노트

반응식

HRID 490092 반응식
C(C1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8](CC1C=CC(OC)=CC=1)[N:7]=[C:6]2[CH3:21])#N.C([N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])C.N1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.[SH2:35].C([O:39][CH2:40]C)(=O)C>>[CH3:40][O:39][C:32]1[CH:33]=[CH:34][C:28]([CH2:27][N:24]=[C:25]([C:26]2[CH:4]=[C:5]3[C:9](=[CH:10][CH:11]=2)[NH:8][N:7]=[C:6]3[CH3:21])[SH:35])=[CH:30][CH:31]=1

참가 물질

5

반응물 4

HCID 402Hydrogen SulfideHCID 8857Ethyl AcetateHCID 22561186Pyridine triethylamineHCID 689992085-cyano-N-(4-methoxybenzyl)-3-methylindazole

생성물 1

HCID 178491226HCID 178491226, 화합물

실험 절차

To a solution of 5-cyano-N-(4-methoxybenzyl)-3-methylindazole 106 (0.25 g, 0.903 mmol) in 10% v/v triethylamine-pyridine (10 mL) was bubbled hydrogen sulfide gas for 10 minutes. The reaction mixture was stirred at room temperature for 16 hours. Ethyl acetate (100 mL) was added and the organic layer was washed with water, 1% aqueous citric acid and brine. The organic layer was dried over sodium sulfate. The organic solvent was evaporated under reduced pressure to yield N-(4-methoxybenzyl)-3-methylindazole-5-carboximidothioic acid 107 which was used in the next step without further purification.

후처리

  1. washthe organic layer was washed with water, 1% aqueous citric acid and brine
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. customThe organic solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-24d66aa78e084400a3003ed46a81d3c7
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528132B2

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