Dimethylmaleic anhydride → 2-chloro-5-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzenesulfonamide

HRID 4901

반응식

HRID 4901 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:12])=[C:6]([S:8]([NH2:11])(=[O:10])=[O:9])[CH:7]=1.[CH3:13][C:14]1[C:15]([O:17][C:18](=O)[C:19]=1[CH3:20])=[O:16]>N1C=CC=CC=1>[Cl:12][C:5]1[CH:4]=[CH:3][C:2]([N:1]2[C:15](=[O:16])[C:14]([CH3:13])=[C:19]([CH3:20])[C:18]2=[O:17])=[CH:7][C:6]=1[S:8]([NH2:11])(=[O:9])=[O:10]

참가 물질

4

반응물 2

HCID 13010Dimethylmaleic anhydrideHCID 748345-Amino-2-chlorobenzenesulfonamide

생성물 1

HCID 148372102-chloro-5-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzenesulfonamide수율 93%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

In 3 ml of pyridine, 1 mmol of 5-amino-2-chlorobenzenesulfonamide and 1.05 mmol of 2,3-dimethylmaleic anhydride were stirred at 90-100° C. for 9 hours. Pyridine was then distilled off from the reaction mixture, followed by the addition of 20 ml of ice water and 0.1 ml of 35% hydrochloric acid to the solid residue. After the mixture thus formed was stirred for 20 minutes, the resulting precipitate was collected by filtration and then dried in air. Yield: 93%. Its physicochemical properties are shown in Table 8.

후처리

  1. distillationPyridine was then distilled off from the reaction mixture
  2. additionfollowed by the addition of 20 ml of ice water and 0.1 ml of 35% hydrochloric acid to the solid residue
  3. customAfter the mixture thus formed
  4. filtrationthe resulting precipitate was collected by filtration
  5. customdried in air

출처 및 근거

ORD 기록
ord-0486b163d93d4c4098549fecca2a4eab
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242894

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