Ethyl Acetate → 3-Amino-5-bromo-1H-indazole
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[C:7]#[N:8].[NH2:11][NH2:12].C(OCC)(=O)C>C(O)C>[NH2:8][C:7]1[C:6]2[C:5](=[CH:4][CH:3]=[C:2]([Br:1])[CH:9]=2)[NH:12][N:11]=1참가 물질
5
반응 조건
- 온도
- 140 °C
실험 절차
To a solution of 5-bromo-2-fluorobenzonitrile (0.40 g, 2.0 mmol.) in ethanol (3 mL) was added hydrazine (0.64 g, 20 mmol.). The reaction mixture was heated in a microwave reactor at 140° C. for 20 minutes. Ethyl acetate (100 mL) was added. The organic layer was washed with water and brine. The organic layer was dried over sodium sulfate. The organic solvent was evaporated under reduced pressure to yield 3-amino-5-bromoindazole 165 (0.41 g, 1.93 mmol.). The crude product was used in the next step without further purification.
후처리
- washThe organic layer was washed with water and brine
- dry with materialThe organic layer was dried over sodium sulfate
- customThe organic solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-c3a1255627004dadba6c59dd093873cb
- 출처 데이터셋
- uspto-grants-2009_05
- 특허 번호
- US07528132B2
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