Dimethylmaleic anhydride → methyl 2-(aminosulfonyl)-4-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzoate

HRID 4902

반응식

HRID 4902 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([S:12]([NH2:15])(=[O:14])=[O:13])[CH:3]=1.[CH3:16][C:17]1[C:18]([O:20][C:21](=O)[C:22]=1[CH3:23])=[O:19]>C(O)(=O)C>[NH2:15][S:12]([C:4]1[CH:3]=[C:2]([N:1]2[C:18](=[O:19])[C:17]([CH3:16])=[C:22]([CH3:23])[C:21]2=[O:20])[CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7])(=[O:13])=[O:14]

참가 물질

4

반응물 2

HCID 13010Dimethylmaleic anhydrideHCID 10977277Methyl 4-amino-2-sulfamoylbenzoate

생성물 1

HCID 14837212methyl 2-(aminosulfonyl)-4-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzoate수율 43%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

In 3 ml of acetic acid, 1 mmol of methyl 4-amino-2-(aminosulfonyl)benzoate and 1.05 mmol of 2,3-dimethylmaleic anhydride were stirred at 80° C. for 40 hours. Acetic acid was then distilled off from the reaction mixture, followed by the addition of 20 ml of ice water to the oily residue. After the mixture thus formed was stirred for 2 hours, the resulting precipitate was collected by filtration and then dried in air. Yield: 43%. Its physicochemical properties are shown in Table 8.

후처리

  1. distillationAcetic acid was then distilled off from the reaction mixture
  2. additionfollowed by the addition of 20 ml of ice water to the oily residue
  3. customAfter the mixture thus formed
  4. filtrationthe resulting precipitate was collected by filtration
  5. customdried in air

출처 및 근거

ORD 기록
ord-b9ac6e1cabe64925a2abe6ef104073ff
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242894

연결된 노트

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