Triethylamine → HCID 57674748, 화합물

HRID 490224노트

반응식

HRID 490224 반응식
C(O[CH:4]=[C:5]([C:8]#[N:9])[C:6]#[N:7])C.Cl.[NH2:11][CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)=[O:16].C(N(CC)CC)C>C(#N)C>[C:6]([C:5]([C:8]#[N:9])=[CH:4][NH:11][CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)=[O:16])#[N:7]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 671522-(Ethoxymethylene)propanedinitrileHCID 23033068N-(2-aminoethyl)-4-fluorobenzamide hydrochloride

생성물 1

HCID 57674748HCID 57674748, 화합물수율 68.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

After adding acetonitrile (100 mL) and ethoxymethylenemalononitrile (4.5 g) to N-(2-aminoethyl)(4-fluorophenyl)carboxamide hydrochloride (8.3 g), a solution of triethylamine (4.5 g) in acetonitrile (20 mL) was added thereto. After stirring at room temperature for 15 minutes, the solvent was distilled off under reduced pressure, water and ethyl acetate were added to the residue, and the mixture was stirred. The precipitated solid was filtered out to obtain the crude title compound (6.5 g) as a brown solid.

후처리

  1. distillationthe solvent was distilled off under reduced pressure, water and ethyl acetate
  2. additionwere added to the residue
  3. stirringthe mixture was stirred
  4. filtrationThe precipitated solid was filtered out

출처 및 근거

ORD 기록
ord-7113afc0302347c893befd036be00967
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528140B2

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