2-Bromo-4-(trifluoromethyl)-1,3-thiazole → (R)-1-(4-Trifluoromethylthiazol-2-yl)pyrrolidin-3-ylamine

HRID 490302노트

반응식

HRID 490302 반응식
Br[C:2]1[S:3][CH:4]=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1.C(OC(=O)[NH:17][C@@H:18]1[CH2:22][CH2:21][N:20](C2C(C(F)(F)F)=CC=CN=2)[CH2:19]1)(C)(C)C.FC(F)(F)C1C(N2CC[C@@H](N)C2)=NC=CC=1>>[F:8][C:7]([F:10])([F:9])[C:5]1[N:6]=[C:2]([N:20]2[CH2:21][CH2:22][C@@H:18]([NH2:17])[CH2:19]2)[S:3][CH:4]=1

참가 물질

4

반응물 3

HCID 231498872-Bromo-4-(trifluoromethyl)-1,3-thiazoleHCID 67001808[(R)-1-(3-Trifluoromethylpyridin-2-yl)pyrrolidin-3-yl]-carbamic acid tert-butyl esterHCID 68801104(R)-1-(3-Trifluoromethylpyridin-2-yl)pyrrolidin-3-ylamine

생성물 1

HCID 69070055(R)-1-(4-Trifluoromethylthiazol-2-yl)pyrrolidin-3-ylamine

실험 절차

Prepared from 2-bromo4-trifluoromethylthiazole (J. A. Edwards Ger. Offen., 2252070, 1973) in a manner similar to that described in D1 and D2.

출처 및 근거

ORD 기록
ord-1b9ce711dae6401b9f02d72a7769ccdf
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528151B2

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