(2-Methyl-furan-3-yl)-acetic acid ethyl ester → 2-(2-Methylfuran-3-yl)ethan-1-ol

HRID 490360노트

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HRID 490360 반응식
C([O:3][C:4](=O)[CH2:5][C:6]1[CH:10]=[CH:9][O:8][C:7]=1[CH3:11])C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:11][C:7]1[O:8][CH:9]=[CH:10][C:6]=1[CH2:5][CH2:4][OH:3]

참가 물질

4

반응물 2

HCID 14755481(2-Methyl-furan-3-yl)-acetic acid ethyl esterHCID 21226445Aluminium lithium hydride

생성물 1

HCID 184446362-(2-Methylfuran-3-yl)ethan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
0 °C

실험 절차

A solution of (2-methyl-furan-3-yl)-acetic acid ethyl ester (11.8 g, 70.2 mmoles) in tetrahydrofuran (50 ml) was added to a stirred suspension of lithium aluminium hydride (2.66 g, 70.2 mmoles) under a nitrogen atmosphere and with cooling to 0° C. When the addition was complete the mixture was stirred at room temperature for 3 hours, then quenched by the addition of excess acetone. After acidifying with 10% aqueous hydrochloric acid the mixture was extracted three times with diethyl ether. The combined extracts were dried and evaporated to afford crude 2-(2-methyl-furan-3-yl)-ethanol as a yellow oil.

후처리

  1. additionWhen the addition
  2. customquenched by the addition of excess acetone
  3. extractionwas extracted three times with diethyl ether
  4. customThe combined extracts were dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-5e5871ca7c3c4ffdb7014e78ba0862f7
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528157B2

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