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Water → HCID 67147578, 화합물

HRID 490429
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HRID 490429 반응식
C(=O)([O-])[O-].[K+].[K+].[C:7]([O:11][CH3:12])(=[O:10])[CH:8]=[CH2:9].[CH3:13][O:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][C:23]=1[O:24][CH3:25])[NH:20][CH:19]=[C:18]2[C:26]1[N:34]([S:35]([C:38]2[CH:43]=[CH:42][C:41]([CH3:44])=[CH:40][CH:39]=2)(=[O:37])=[O:36])[C:29]2=[N:30][CH:31]=[CH:32][CH:33]=[C:28]2[CH:27]=1.O>CN(C)C=O.C(OCC)(=O)C>[CH3:13][O:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][C:23]=1[O:24][CH3:25])[N:20]([CH2:9][CH2:8][C:7]([O:11][CH3:12])=[O:10])[CH:19]=[C:18]2[C:26]1[N:34]([S:35]([C:38]2[CH:39]=[CH:40][C:41]([CH3:44])=[CH:42][CH:43]=2)(=[O:37])=[O:36])[C:29]2=[N:30][CH:31]=[CH:32][CH:33]=[C:28]2[CH:27]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 962WaterHCID 7294Methyl AcrylateHCID 11430Potassium CarbonateHCID 22477225HCID 22477225, 화합물

생성물 1

HCID 67147578HCID 67147578, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매
HCID 8857
Ethyl Acetate
용매

실험 절차

0.34 g of potassium carbonate and 0.243 ml of methyl acrylate are added, dropwise, to a solution of 1 g of 2-(5,6-dimethoxy-1H-indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine in 20 ml of anhydrous dimethylformamide, under an inert argon atmosphere at a temperature in the region of 20° C. The reaction medium is agitated at the same temperature for 16 hours. 20 ml of water and 20 ml of ethyl acetate are added. After separation by settling out, the organic phase is dried over sodium sulfate, filtered, and then concentrated under reduced pressure. After purification by flash chromatography (silica, dichloromethane as eluent, argon), the fractions containing the product are concentrated under reduced pressure. 1 g of methyl 3-{5,6-dimethoxy-3-[1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]indol-1-yl}propionate is thus obtained, the characteristics of which are as follows:

후처리

  1. customin the region of 20° C
  2. customAfter separation
  3. dry with materialthe organic phase is dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customAfter purification by flash chromatography (silica, dichloromethane as eluent, argon)
  7. additionthe fractions containing the product
  8. concentrationare concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3a287ef6bb1648308a0371853c7dcc7d
출처 데이터셋
uspto-grants-2009_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07528147B2

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