5-Benzyl-octahydropyrrolo(3,4-c)pyrrole-1,3-dione → Perhydropyrrolo(3,4-c)pyrrole-1,3-dione

HRID 490471

반응식

HRID 490471 반응식
C([N:8]1[CH2:12][CH:11]2[C:13](=[O:17])[NH:14][C:15](=[O:16])[CH:10]2[CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[C:13]1(=[O:17])[CH:11]2[CH2:12][NH:8][CH2:9][CH:10]2[C:15](=[O:16])[NH:14]1

참가 물질

4

반응물 1

HCID 45649025-Benzyl-octahydropyrrolo(3,4-c)pyrrole-1,3-dione

생성물 1

HCID 21476587Perhydropyrrolo(3,4-c)pyrrole-1,3-dione

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution 5-benzyl-tetrahydropyrrolo[3,4-c]pyrrole-1,3-dione, (11.5 g; 49.9 mmol) in ethanol (200 ml) is placed in a 1000 ml autoclave and palladium-on-charcoal (5%; 2 g; 0.9 mmol) is then added. After having purged the reactor with nitrogen, the autoclave is placed under 58 bars of hydrogen at 70° C. for 16 hours. After returning to 20° C., filtration and washing of the catalyst, evaporation is carried out under reduced pressure and the solid obtained is then recrystallized from methanol (100 ml) and drying is carried out under reduced pressure at constant weight. Perhydropyrrolo[3,4-c]pyrrole-1,3-dione, (3.6 g) is isolated, the characteristics of which are as follows:

후처리

  1. additionis then added
  2. customAfter having purged the reactor with nitrogen
  3. customAfter returning to 20° C.
  4. filtrationfiltration
  5. washwashing of the catalyst, evaporation
  6. customthe solid obtained
  7. customis then recrystallized from methanol (100 ml)
  8. customdrying

출처 및 근거

ORD 기록
ord-3c9ae7d963e149698ed2d87e386aa416
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528147B2

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