Aluminium lithium hydride → [5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol

HRID 49053노트

반응식

HRID 49053 반응식
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([CH2:15][CH2:16][CH2:17][N:18]([CH2:21][CH3:22])[CH2:19][CH3:20])=[CH:10][CH:9]=2)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:21]([N:18]([CH2:19][CH3:20])[CH2:17][CH2:16][CH2:15][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH2:4][OH:3])=[CH:14]2)[CH3:22]

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 695872925-(3-Diethylamino-propyl)-1H-indole-2-carboxylic acid ethyl ester

생성물 1

HCID 22042151[5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol수율 66%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

5-(3-Diethylamino-propyl)-1H-indole-2-carboxylic acid ethyl ester (1.2 g, 3.97 mmol) in tetrahydrofuran (48 mL) was added dropwise to the lithium aluminum hydride (602 mg, 15.87 mmol) stirred in tetrahydrofuran (30 mL) under nitrogen. After stirring for 2 hours, the reaction was quenched in water (0.6 mL), 15% sodium hydroxide (0.6 mL) and then water (1.8 mL). The mixture was stirred overnight. The precipitate was filtered off and the filtrate was concentrated to give 680 mg (66%) of [5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol.

후처리

  1. customthe reaction was quenched in water (0.6 mL)
  2. stirringThe mixture was stirred overnight
  3. filtrationThe precipitate was filtered off
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-413f40fc0a4c4fd5835825d0b304ca37
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706709B2

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