1-Isobutyl-5-nitro-1,2-dihydro-indazol-3-one → 5-Amino-1-isobutyl-1,2-dihydro-indazol-3-one

HRID 490556노트

반응식

HRID 490556 반응식
[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([N+:14]([O-])=O)=[CH:11][CH:12]=2)[C:7](=[O:17])[NH:6]1)[CH:2]([CH3:4])[CH3:3]>CO.[Pd]>[NH2:14][C:10]1[CH:9]=[C:8]2[C:13](=[CH:12][CH:11]=1)[N:5]([CH2:1][CH:2]([CH3:3])[CH3:4])[NH:6][C:7]2=[O:17]

참가 물질

4

반응물 1

HCID 688321981-Isobutyl-5-nitro-1,2-dihydro-indazol-3-one

생성물 1

HCID 688331235-Amino-1-isobutyl-1,2-dihydro-indazol-3-one수율 76.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

To a solution of 1-isobutyl-5-nitro-1,2-dihydro-indazol-3-one (0.9 g) in MeOH (50 mL) was added Pd/C(10%) catalyst (0.3 g) and the reaction mixture was stirred for 1 hour at 40° C. under a hydrogen atmosphere using a balloon. After this time the reaction mixture was filtered through Celite® which was washed with more EtOAc. The combined organic solution was evaporated in vacuo for afford the desired 5-amino-1-isobutyl-1,2-dihydro-indazol-3-one (0.6 g) which was taken into the next reaction without further purification. MS (ESI+): 206.1 ([M+H]+).

후처리

  1. filtrationAfter this time the reaction mixture was filtered through Celite® which
  2. washwas washed with more EtOAc
  3. customThe combined organic solution was evaporated in vacuo

출처 및 근거

ORD 기록
ord-57d0e1d238f14ec2ba5bc8a0496a8774
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528158B2

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