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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 490635생성일: 2026년 10월 25일

1-(m-Tolyl)piperazine → [(2s,4s)-1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidin-2-yl]-(4-m-tolyl-piperazin-1-yl)-methanone

https://huagongshe.com/reaction/490635

반응식

참여 물질

역할이름HCID투입량
반응물1-(m-Tolyl)piperazineHCID 83111—
반응물1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carboxylic acidHCID 86625301—
생성물[(2s,4s)-1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidin-2-yl]-(4-m-tolyl-piperazin-1-yl)-methanoneHCID 874401428.5%

반응 단계

As described for Example 56d, 1-benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carboxylic acid (65 mg, 0.146 mmol) was converted, using 1-m-tolyl-piperzine instead of 1-(3-trifluoromethyl-phenyl)-piperazine, to the title compound (7.5 mg, 8.5%) as light yellow oil. MS m/e=605.4 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07528136B2
출처 데이터셋uspto-grants-2009_05
ORD IDord-d2d32b50641540d4be6fa03fbb04c6bd
출처 메모uspto-grants-2009_05