Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(4-Methyl-2-(4-(trifluoromethyl)phenyl)-1,3-thiazol-5-yl)methanol → 4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (4-Methyl-2-(4-(trifluoromethyl)phenyl)-1,3-thiazol-5-yl)methanol | HCID 2783005 | — |
| 촉매 | Manganese dioxide | HCID 14801 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde | HCID 2782899 | 100.7% |
반응 단계
A mixture of [4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol (5.0 g, 18.3 mmol) and MnO2 (2.4 g, 27.5 mmol) in chloroform (110 mL) are heated to reflux for 48 hrs, cooled to room temperature, filtered through celite. Concentration yields 5 gram of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07528160B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-64ad9ae807ed4a35b3be697a5a0e349d |
| 출처 메모 | uspto-grants-2009_05 |