Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 49088생성일: 2026년 10월 24일
Piperidine → 2-Oxo-3-[5-(2-pyrrolidin-1-yl-ethoxy)-1H-indol-2-ylmethylene]-2,3-dihydro-1H-indole-5-sulfonic acid amide
https://huagongshe.com/ko/reaction/49088
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 2-Oxoindoline-5-sulfonamide | HCID 10198232 | — |
| 반응물 | 5-(2-pyrrolidin-1-yl-ethoxy)-1H-indole-2-carbaldehyde | HCID 22042092 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Oxo-3-[5-(2-pyrrolidin-1-yl-ethoxy)-1H-indol-2-ylmethylene]-2,3-dihydro-1H-indole-5-sulfonic acid amide | HCID 69344083 | 80% |
반응 단계
A mixture of 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide (28 mg, 0.13 mmol), 5-(2-pyrrolidin-1-yl-ethoxy)-1H-indole-2-carbaldehyde (34 mg, 0.13 mmol) and piperidine (0.1 mL) in ethanol (1 mL) was heated at 90° C. for 2 hours. The reaction was cooled at 0° C. for overnight. The precipitate was collected by vacuum filtration, washed with cold ethanol and dried to give 47 mg (80%) of the title compound as an orange solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06706709B2 |
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| 출처 데이터셋 | uspto-grants-2004_03 |
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| ORD ID | ord-22473575d84e496bb2a3edaf31178be3 |
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| 출처 메모 | uspto-grants-2004_03 |
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