Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 49089생성일: 2026년 10월 24일
Piperidine → 3-[5-(2-Morpholin-4-yl-ethoxy)-1H-indol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide
https://huagongshe.com/ko/reaction/49089
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 2-Oxoindoline-5-sulfonamide | HCID 10198232 | — |
| 반응물 | 5-(2-morpholin-4-yl-ethoxy)-1H-indole-2-carbaldehyde | HCID 22042109 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-[5-(2-Morpholin-4-yl-ethoxy)-1H-indol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide | HCID 69343407 | 73.7% |
반응 단계
A mixture of 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide (27 mg, 0.12 mmol), 5-(2-morpholin-4-yl-ethoxy)-1H-indole-2-carbaldehyde (30 mg, 0.11 mmol) and piperidine (0.1 mL) in ethanol (1 mL) was heated at 90° C. for 2 hours. The reaction was cooled at 0° C. for overnight. The precipitate was collected by vacuum filtration, washed with cold ethanol and dried to give 38 mg (62%) of the title compound as an orange solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06706709B2 |
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| 출처 데이터셋 | uspto-grants-2004_03 |
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| ORD ID | ord-e3f6aac9d2af4f57ace14d07b31f7923 |
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| 출처 메모 | uspto-grants-2004_03 |
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