Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
phenylalaninol, (R)- → 1-Ethyl-N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-4-(tetrahydro-2H-pyran 4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | phenylalaninol, (R)- | HCID 853475 | — |
| 반응물 | 1-Ethyl-N-[(1R)-2-hydroxy-1-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide | HCID 11281295 | — |
| 반응물 | 1-Ethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid | HCID 53487829 | — |
| 생성물 | 1-Ethyl-N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-4-(tetrahydro-2H-pyran 4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide | HCID 57675224 | — |
반응 단계
Intermediate 45 was prepared from Intermediate 17 and (2R)-2-amino-3-phenyl-1-propanol (commercially available from Aldrich) using an analagous method to that for Intermediate 42. LCMS showed MH+=424; TRET=2.59 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07528148B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-0b1b452c082740d29ac3d49a51d0c15e |
| 출처 메모 | uspto-grants-2009_05 |