1-Methyl-2-nitro-3-(trifluoromethyl)benzene → 2-Amino-3-methylbenzotrifluoride

HRID 491146노트

반응식

HRID 491146 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:10])[F:9])[C:3]=1[N+:12]([O-])=O.[H][H]>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:9])([F:10])[F:11])[C:3]=1[NH2:12]

참가 물질

5

반응물 2

HCID 134554311-Methyl-2-nitro-3-(trifluoromethyl)benzeneHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 133182332-Amino-3-methylbenzotrifluoride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A suspension of 50 g (0.24 mol) 1-methyl-2-nitro-3-trifluoromethyl-benzene and 4.4 g 10% Pd/C in 300 mL MeOH was hydrogenated at RT and 3000 hPa hydrogen pressure until the theoretical amount of hydrogen had been taken up. The catalyst was filtered off, washed with MeOH and the filtrate was evaporated down. The crude product was further reacted without purification.

후처리

  1. customwas hydrogenated at RT
  2. filtrationThe catalyst was filtered off
  3. washwashed with MeOH
  4. customthe filtrate was evaporated down
  5. customThe crude product was further reacted without purification

출처 및 근거

ORD 기록
ord-2e76dbfa524e4d0db4d230b5fb152532
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528129B2

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