2-Bromoethanol → 2-[4-(3-Bromo-phenyl)-piperidin-1-yl]-ethanol
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Br[CH2:15][CH2:16][OH:17].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:13][CH2:12][N:11]([CH2:15][CH2:16][OH:17])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1참가 물질
5
실험 절차
4-(3-Bromo-phenyl)-piperidine (1.2 g, 4.8 mmol) and 2-bromoethanol (0.72 mL, mmol) were diluted with DMF (20 mL) and treated with potassium carbonate (2.7 g, 20 mmol). These were stirred at ambient temperature for 18 then poured onto water and extracted with ethyl acetate. Organic phase then washed with brine, dried over sodium sulfate, filtered and evaporated to clear oil (0.6 g, 44%).
후처리
- additionthen poured onto water
- extractionextracted with ethyl acetate
- washOrganic phase then washed with brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customevaporated to clear oil (0.6 g, 44%)
출처 및 근거
- ORD 기록
- ord-a650b9ebc4244226bdd88bf3f837c996
- 출처 데이터셋
- uspto-grants-2009_05
- 특허 번호
- US07528143B2
반응 노트
불러오는 중…