Ethanol → 6-Pyridin-3-yl-1,3-dihydro-indol-2-one

HRID 49122

반응식

HRID 49122 반응식
Br[C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.C(O)C.C(=O)([O-])[O-].[Na+].[Na+].C(O)(O)CC.[N:26]1[CH:31]=[CH:30][CH:29]=[C:28](B(O)O)[CH:27]=1>C1(C)C=CC=CC=1.C(OCC)(=O)C>[N:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:2]2[CH:10]=[C:9]3[C:5]([CH2:6][C:7](=[O:11])[NH:8]3)=[CH:4][CH:3]=2)[CH:27]=1

참가 물질

7

반응물 4

HCID 702EthanolHCID 10340Sodium CarbonateHCID 27732896-bromo-2,3-dihydro-1H-indol-2-oneHCID 69587225Pyridine-3-boronic acid propane diol

생성물 1

HCID 219155796-Pyridin-3-yl-1,3-dihydro-indol-2-one수율 42%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8857Ethyl Acetate용매

반응 조건

온도
100 °C

실험 절차

To a solution of 6-bromo-2-oxindole (4 g, 26.3 mmol) dissolved in 60 mL of toluene and 60 mL of ethanol with stirring and a little heating tetrakis(triphenyl-phosphine)palladium(0) (2.3 g, 1.9 mmol) was added followed by a 2M aqueous solution of sodium carbonate (50 mL, 100 mmol) and pyridine-3-boronic acid propane diol (5 g, 30.7 mmol). The mixture was heated in a 100° C. oil bath for 12 hours. The cooled reaction was diluted with ethyl acetate (500 mL), washed with saturated aqueous sodium bicarbonate (200 mL), water (200 mL) and brine (200 mL). The organic layer was dried with magnesium sulfate and concentrated to afford a brown solid. The residue was triturated with methylene chloride/diethyl ether to give 2.32 g (42%) of 6-pyridin-3-yl-1,3-dihydro-indol-2-one as a brown solid.

후처리

  1. additionwas added
  2. customThe cooled reaction
  3. washwashed with saturated aqueous sodium bicarbonate (200 mL), water (200 mL) and brine (200 mL)
  4. dry with materialThe organic layer was dried with magnesium sulfate
  5. concentrationconcentrated
  6. customto afford a brown solid
  7. customThe residue was triturated with methylene chloride/diethyl ether

출처 및 근거

ORD 기록
ord-c51a563b1d5e48e99b901ce71d587a2a
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706709B2

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