3-Nitro-biphenyl-4-acetic acid → 6-Phenyl-1,3-dihydro-indol-2-one
반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][C:11](O)=[O:12])([O-])=O>C(O)(=O)C.[Fe]>[C:14]1([C:6]2[CH:5]=[C:4]3[C:9]([CH2:10][C:11](=[O:12])[NH:1]3)=[CH:8][CH:7]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1참가 물질
4
실험 절차
Iron chips (2.6 g) were added all at once to 4.5 g of 3-nitrobiphenyl-4-acetic acid in 40 mL of acetic acid. The mixture was heated to reflux for 2 hours, concentrated to dryness and taken up in ethyl acetate. The solids were removed by filtration and the filtrate was washed twice with 1N hydrochloric acid and brine and dried over anhydrous sodium sulfate. The filtrate was concentrated to give 3.4 g (93% yield) of 6-phenyl-2-oxindole as a light brown solid.
후처리
- temperatureThe mixture was heated
- temperatureto reflux for 2 hours
- concentrationconcentrated to dryness
- customThe solids were removed by filtration
- washthe filtrate was washed twice with 1N hydrochloric acid and brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-d27c432970db48f6aa761702e7d002d4
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06706709B2
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