3-Methoxytyramine → 4-[2-(5-Chlorothieno[2,3-d]pyrimidin-4-ylamino)ethyl]-2-methoxyphenol

HRID 491266

반응식

HRID 491266 반응식
Cl[C:2]1[C:3]2[C:10]([Cl:11])=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([O:22][CH3:23])[CH:16]=1.C(N(CC)CC)C>CN(C=O)C.O>[Cl:11][C:10]1[C:3]2[C:2]([NH:12][CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([O:22][CH3:23])[CH:16]=3)=[N:7][CH:6]=[N:5][C:4]=2[S:8][CH:9]=1

참가 물질

6

반응물 3

HCID 16693-MethoxytyramineHCID 8471TriethylamineHCID 157457684,5-Dichlorothieno[2,3-d]pyrimidine

생성물 1

HCID 688569804-[2-(5-Chlorothieno[2,3-d]pyrimidin-4-ylamino)ethyl]-2-methoxyphenol수율 76%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A solution of 4,5-dichlorothieno[2,3-d]pyrimidine (2.0 g, 9.8 mmol), 4-(2-aminoethyl)-2-methoxyphenol (1.8 g, 10.7 mmol) and triethylamine (1.2 g, 11.8 mmol) in DMF (15 mL) was stirred overnight. The solution was diluted with H2O and the product collected by filtration yielding an off white powder, 2.5 g, 7.4 mmol, 76 percent yield.

후처리

  1. filtrationthe product collected by filtration
  2. customyielding an off white powder, 2.5 g, 7.4 mmol, 76 percent yield

출처 및 근거

ORD 기록
ord-2815d09f82de493285b790fdf2f57820
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531482B2

연결된 노트

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