Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 4-Fluoro-3'-methoxy-3-nitrobiphenyl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | (3-Methoxyphenyl)boronic acid | HCID 2734370 | — |
| 반응물 | 4-Bromo-1-fluoro-2-nitrobenzene | HCID 2736328 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-Fluoro-3'-methoxy-3-nitrobiphenyl | HCID 10490702 | 77% |
반응 단계
Tetrakis(triphenylphosphine)palladium (0.7 g) was added to a mixture of 3.8 g of 3-methoxyphenylboronic acid, 5 g of 5-bromo-2-fluoronitrobenzene and 11 mL of 2M sodium carbonate solution in 100 mL of toluene. The mixture was heated to reflux for 2 hours, diluted with water and extracted with ethyl acetate. The ethyl acetate was washed with saturated sodium bicarbonate, brine, dried, and concentrated to give an oily solid. The solid was purified by column chromatography on silica gel in ethyl acetate:hexane 1:6 to give 4.3 g (77% yield) of 4-fluoro-3′-methoxy-3-nitrobiphenyl.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06706709B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-66dd4ba7c2f54d8aa9394a11c82c0559 |
| 출처 메모 | uspto-grants-2004_03 |