Methanol → HCID 67304384, 화합물
반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([C:13](O)=[O:14])[N:10]=[CH:9]2)=[CH:4][CH:3]=1.CO>C1COCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([CH2:13][OH:14])[N:10]=[CH:9]2)=[CH:6][CH:7]=1참가 물질
4
실험 절차
1-(4-Fluoro-phenyl)-1H-imidazole-4-carboxylic acid is dissolved in THF. Borane tetrahydrofuran complex in THF is added dropwise. The reaction is refluxed for 2 h and stirred at room temperature overnight. The reaction mixture is then cooled to 0° C. and methanol is added dropwise. The solvents are evaporated and the residue is taken up in HCl and refluxed for 2 h. The reaction mixture is then cooled to 0° C. and sodium hydroxide solution is added dropwise. The desired compound [1-(4-fluoro-phenyl)-1H-imidazol-4-yl]-methanol is obtained.
후처리
- temperatureThe reaction is refluxed for 2 h
- temperatureThe reaction mixture is then cooled to 0° C.
- customThe solvents are evaporated
- temperaturerefluxed for 2 h
- temperatureThe reaction mixture is then cooled to 0° C.
- additionsodium hydroxide solution is added dropwise
출처 및 근거
- ORD 기록
- ord-dc9fc214cc8348848df8b0d9728069f0
- 출처 데이터셋
- uspto-grants-2009_05
- 특허 번호
- US07531529B2
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