HCID 178418361, 화합물 → Methyl 5-amino-1H-pyrazole-3-carboxylate

HRID 491394노트

반응식

HRID 491394 반응식
[N+:1]([C:4]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[NH:6][N:5]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[NH:6][N:5]=1

참가 물질

5

반응물 2

HCID 178418361HCID 178418361, 화합물HCID 178498471HCID 178498471, 화합물

생성물 1

HCID 18445864Methyl 5-amino-1H-pyrazole-3-carboxylate수율 111.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A suspension of methyl 3-nitro-1H-pyrazole-5-carboxylate (10 g, 58.4 mmol) and 10% Pd on charcoal (1.2 g) in methanol (150 Ml) was stirred under 50 psi pressure of hydrogen gas for 16 h. The reaction mixture was filtered over a bed of Celite and the filtrate was concentrated to give 9.2 g of methyl 3-amino-1H-pyrazole-5-carboxylate which was used as such in the next reaction. MS (ESI) m/z 142.3 (M+H).

후처리

  1. filtrationThe reaction mixture was filtered over a bed of Celite
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-6d85ddd4f1b74951bd0bdff023564b68
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531539B2

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