HCID 16119618, 화합물 → HCID 57678429, 화합물

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[F:1][C:2]1[C:16](I)=[CH:15][C:5]([O:6][C:7]2[C:8]([NH2:14])=[N:9][C:10]([NH2:13])=[N:11][CH:12]=2)=[C:4]([CH:18]([CH3:20])[CH3:19])[CH:3]=1.[C:21]([C:23]1C(F)=CC(C(C)C)=C(C=1)OC1C(N)=NC(N)=NC=1)#[CH:22]>>[F:1][C:2]1[C:16]([C:22]#[C:21][CH3:23])=[CH:15][C:5]([O:6][C:7]2[C:8]([NH2:14])=[N:9][C:10]([NH2:13])=[N:11][CH:12]=2)=[C:4]([CH:18]([CH3:20])[CH3:19])[CH:3]=1

참가 물질

반응물 2

HCID 16119618HCID 16119618, 화합물

HCID 576784025-[4-Fluoro-5-iodo-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine

생성물 1

HCID 57678429HCID 57678429, 화합물

실험 절차

Similarly prepared from 5-(4-fluoro-5-iodo-2-isopropyl-phenoxy)-pyrimidine -2,4-diamine using the procedure of step 8 of example 1 was 5-(5-Ethynyl-4-fluoro-2-isopropyl-phenoxy)-pyrimidine -2,4-diamine, MS (M+H)=289.

출처 및 근거

ORD 기록: ord-91260a423553478b9ec6022edbd1be16
출처 데이터셋: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07531547B2

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