5-Decene → 4-{4-[5-(2-ethoxy-ethyl)-2,4,6-trioxo-hexahydro-pyrimidin-5-yloxy]-phenoxy}-N-methyl-benzamide

HRID 49153

반응식

HRID 49153 반응식
[OH:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:16]=[CH:15][C:10]([C:11]([NH:13][CH3:14])=[O:12])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.Br[C:20]1([CH2:29][CH2:30][O:31][CH2:32][CH3:33])[C:25](=[O:26])[NH:24][C:23](=[O:27])[NH:22][C:21]1=[O:28].CCCCC=CCCCC.C1(F)(C2(F)OC(C(F)(F)F)(C(F)(F)F)OC2(F)F)OC(C(F)(F)F)(C(F)(F)F)OC1(F)F>C(#N)C>[CH2:32]([O:31][CH2:30][CH2:29][C:20]1([O:1][C:2]2[CH:18]=[CH:17][C:5]([O:6][C:7]3[CH:16]=[CH:15][C:10]([C:11]([NH:13][CH3:14])=[O:12])=[CH:9][CH:8]=3)=[CH:4][CH:3]=2)[C:21](=[O:28])[NH:22][C:23](=[O:27])[NH:24][C:25]1=[O:26])[CH3:33]

참가 물질

6

반응물 4

HCID 239165-DeceneHCID 1974084,4',5,5,5',5'-Hexafluoro-2,2,2',2'-tetrakis(trifluoromethyl)-4,4'-bi-1,3-dioxolaneHCID 181840264-(4-hydroxy-phenoxy)-N-methyl-benzamideHCID 219311235-Bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione

생성물 1

HCID 206361284-{4-[5-(2-ethoxy-ethyl)-2,4,6-trioxo-hexahydro-pyrimidin-5-yloxy]-phenoxy}-N-methyl-benzamide수율 15.6%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Following the procedure outlined for the preparation of Example 1 4-(4-hydroxy-phenoxy)-N-methyl-benzamide (0.14 g, 0.58 mmol) was reacted with 5-bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (0.16 g, 0.58 mmol), 1,5,7-trazabicyclo[4.4.0]dec-5-ene bound to polystyrene crosslinked with 2% DVB (PTBD, Fluka, 0.40 g) and 2.0 mL of acetonitrile, affording 4-{4-[5-(2-ethoxy-ethyl)-2,4,6-trioxo-hexahydro-pyrimidin-5-yloxy]-phenoxy}-N-methyl-benzamide (0.040 g) as a colorless solid.

출처 및 근거

ORD 기록
ord-fc9f32ca787f4719a24f9d4f9ee20304
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706723B2

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