2',3'-Difluoroacetophenone → 6-(2,3-Difluorophenyl)nicotinic acid

반응식

[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9](=O)[CH3:10].FC1C=CC(C2C=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][N:20]=2)=CC=1>>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][N:20]=1

참가 물질

반응물 2

HCID 5195502',3'-Difluoroacetophenone

HCID 227301866-(4-Fluorophenyl)nicotinic acid

생성물 1

HCID 247299866-(2,3-Difluorophenyl)nicotinic acid

실험 절차

The title compound was prepared from 2′,3′-difluoroacetophenone using the procedures outlined for 6-(4-fluorophenyl)nicotinic acid (D1-D3).

출처 및 근거

ORD 기록: ord-e1dc58efc2624c599e68c6373f121f1f
출처 데이터셋: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07531558B2

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