1-Bromo-2-Chloroethane → 1-Chloro-2-[(2-chloroethyl)oxy]-4-nitrobenzene
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[OH:11].Br[CH2:13][CH2:14][Cl:15].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[O:11][CH2:13][CH2:14][Cl:15]참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of 2-chloro-5-nitrophenol (4 g, 23 mmol), 1-bromo-2-chloroethane (9 mL, 115 mmol), and K2CO3 (8 g, 58 mmol) in DMF (50 mL) was heated at 80° C. for 18 h. The mixture was diluted with water and extracted several times with EtOAc. The combined organic layers were washed with 1N NaOH (aq) and concentrated in vacuo to yield the title compound and a bromo adduct contaminant.
후처리
- extractionextracted several times with EtOAc
- washThe combined organic layers were washed with 1N NaOH (aq)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-116b6bf81d2f4fffbc832b106ce0266e
- 출처 데이터셋
- uspto-grants-2009_05
- 특허 번호
- US07531553B2
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