HCID 17756185, 화합물 → 4-(2-Methylamino-pyrimidin-4-yloxy)-phenol

HRID 491659노트

반응식

HRID 491659 반응식
C([O:8][C:9]1[CH:23]=[CH:22][C:12]([O:13][C:14]2[CH:19]=[CH:18][N:17]=[C:16]([NH:20][CH3:21])[N:15]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.CCOC(C)=O>[CH3:21][NH:20][C:16]1[N:15]=[C:14]([O:13][C:12]2[CH:22]=[CH:23][C:9]([OH:8])=[CH:10][CH:11]=2)[CH:19]=[CH:18][N:17]=1

참가 물질

4

반응물 1

HCID 17756185HCID 17756185, 화합물

생성물 1

HCID 177565984-(2-Methylamino-pyrimidin-4-yloxy)-phenol

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

[4-(4-Benzyloxy-phenoxy)-pyrimidin-2-yl]-methyl-amine (Step B, 0.75 g, 2.44 mmol) was dissolved in 5 mL MeOH and 10 mL EtOAc. To the argon-degassed solution was added 10% by weight Pd/C (0.15 g). The reaction was stirred vigorously at RT under 1 atm H2 gas for 4 days. The reaction was filtered through Celite® and concentrated in vacuo to yield the title compound. MS (MH+)=218.1; Calc'd 217.23 for C11H11N3O2.

후처리

  1. customTo the argon-degassed solution
  2. additionwas added 10% by weight Pd/C (0.15 g)
  3. filtrationThe reaction was filtered through Celite®
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-321aae7f45ff49a6bce5a0f5b52b9df2
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531553B2

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