Benzyl Isothiocyanate → 4-Benzyl-2-(4-methyl-benzyl)-[1,2,4]thiadiazolidine-3,5-dione

HRID 491694

반응식

HRID 491694 반응식
[CH2:1]([N:8]=[C:9]=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:11][C:12]1[CH:21]=[CH:20][C:15]([CH2:16][N:17]=[C:18]=[O:19])=[CH:14][CH:13]=1.C([O:24]CC)C>>[CH2:1]([N:8]1[C:9](=[O:24])[S:10][N:17]([CH2:16][C:15]2[CH:20]=[CH:21][C:12]([CH3:11])=[CH:13][CH:14]=2)[C:18]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 2346Benzyl IsothiocyanateHCID 3283Diethyl EtherHCID 27333881-(Isocyanatomethyl)-4-methylbenzene

생성물 1

HCID 115369104-Benzyl-2-(4-methyl-benzyl)-[1,2,4]thiadiazolidine-3,5-dione

실험 절차

Reagents: Benzylisothiocyanate (6.5 mmol, 0.85 mL), 4-methylbenzyl-isocyanate (6.5 mmol, 0.90 mL) and SO2Cl2 (6.5 mmol, 0.52 mL) in diethyl ether (25 mL). Isolation: filtration of reaction mixture. Purification: recrystallization from MeOH.

후처리

  1. filtrationIsolation: filtration of reaction mixture
  2. customPurification
  3. customrecrystallization from MeOH

출처 및 근거

ORD 기록
ord-f93899e19c9043dab00b386df106332f
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531561B2

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