참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Hydrofluoric Acid | HCID 14917 | — |
| 반응물 | 2-(4-{[Tert-butyl(dimethyl)silyl]oxy}-3-fluorophenyl)-7-vinyl-1,3-benzoxazole | HCID 86613666 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Prinaberel | HCID 656954 | 81% |
반응 단계
Hydrofluoric acid (48 wt. % in water, 1 mL) was added into a solution of 5-{[tert-butyl)dimethyl)silyl]oxy}-2-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorophenyl)-7-vinyl-1,3-benzoxazole (1.5 g, 3.0 mmol), THF (6 mL) and acetonitrile (3 mL). The reaction mixture was stirred at 65° C. for 8 h, and then poured into water. The precipitated solid was filtered oft and dried. Crystallization of the product from acetone/ethyl ether gave a white solid (0.72 g, 81% yield, m.p. 249-251° C.); MS m/e 272 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07531564B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_05 |
|---|
| ORD ID | ord-1005539dccac438f97327e0bb934516c |
|---|
| 출처 메모 | uspto-grants-2009_05 |
|---|
