7-Bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole → 7-Butyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol

반응식

Br[C:2]1[C:10]2[O:9][C:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17]C)=[CH:13][CH:12]=3)=[N:7][C:6]=2[CH:5]=[C:4]([O:19]C)[CH:3]=1.Br[Zn][CH2:23][CH2:24][CH2:25][CH3:26]>>[CH2:23]([C:2]1[C:10]2[O:9][C:8]([C:11]3[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=3)=[N:7][C:6]=2[CH:5]=[C:4]([OH:19])[CH:3]=1)[CH2:24][CH2:25][CH3:26]

참가 물질

반응물 2

HCID 121489697-Bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole

HCID 178448257HCID 178448257, 화합물

생성물 1

HCID 1354997747-Butyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol

실험 절차

The title compound was prepared in substantially the same manner as described in Example 35, from 7-bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole, and bromo(butyl)zinc. The desired product was obtained as a white solid, m.p. 125-127° C.; MS m/e 282 (M−H)+.

후처리

customThe title compound was prepared in substantially the same manner

출처 및 근거

ORD 기록: ord-915c5398e12d46278c12a3099f3eac7b
출처 데이터셋: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07531564B2

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