3,5-Difluoro-4-methoxybenzoic acid → 7-Bromo-2-(3,5-difluoro-4-hydroxyphenyl)-1,3-benzoxazol-5-ol

HRID 491758노트

반응식

HRID 491758 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:13])[C:10]=1[O:11]C)[C:5]([OH:7])=O.[NH2:14][C:15]1[CH:20]=[C:19]([O:21]C)[CH:18]=[C:17]([Br:23])[C:16]=1O>>[Br:23][C:17]1[C:16]2[O:7][C:5]([C:4]3[CH:8]=[C:9]([F:13])[C:10]([OH:11])=[C:2]([F:1])[CH:3]=3)=[N:14][C:15]=2[CH:20]=[C:19]([OH:21])[CH:18]=1

참가 물질

3

반응물 2

HCID 27369873,5-Difluoro-4-methoxybenzoic acidHCID 111719822-Amino-6-Bromo-4-Methoxyphenol

생성물 1

HCID 1363472837-Bromo-2-(3,5-difluoro-4-hydroxyphenyl)-1,3-benzoxazol-5-ol

실험 절차

The title compound was prepared in substantially the same manner as described in Example 21, from 3,5-difluoro-4-methoxybenzoic acid, and 2-amino-6-bromo-4-methoxyphenol, and was obtained as a white solid, m.p. 270-272 ° C.; MS m/e 340 (M−H)+.

후처리

  1. customwas obtained as a white solid, m.p. 270-272 ° C.

출처 및 근거

ORD 기록
ord-cf28f88133584659b692ad7f3ae23ddf
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531564B2

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