5-Aminovaleric acid → Methyl 5-aminopentanoate hydrochloride

HRID 491836

반응식

HRID 491836 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7].S(Cl)([Cl:11])=O.[CH3:13]O>>[ClH:11].[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH3:13])=[O:7]

참가 물질

4

반응물 3

HCID 1385-Aminovaleric acidHCID 887MethanolHCID 24386Thionyl Chloride

생성물 1

HCID 13672034Methyl 5-aminopentanoate hydrochloride

실험 절차

5-Aminovaleric acid (7.35 g) is dissolved in methanol (50 ml), thereto is added dropwise thionyl chloride (4.9 ml) under ice-cooling, and the reaction solution is warmed to room temperature and stirred for 17 hours. The reaction solution is concentrated under reduced pressure, and the resulting residue is suspended in diethyl ether and the precipitates are collected by filtration to give methyl 5-aminovalerate hydrochloride (9.93 g).

후처리

  1. temperaturecooling
  2. concentrationThe reaction solution is concentrated under reduced pressure
  3. filtrationthe precipitates are collected by filtration

출처 및 근거

ORD 기록
ord-a2828dee971c45bdae4a7aedd612643c
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531537B2

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