Ethyl Acetate → 4-Formyl-5-nitro-2-phenoxypyridine

HRID 491865노트

반응식

HRID 491865 반응식
CN(C)C=[CH:4][C:5]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][N:8]=[C:7]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:6]=1.I([O-])(=O)(=O)=[O:23].[Na+].CCOC(C)=O>C1COCC1.O>[N+:11]([C:10]1[C:5]([CH:4]=[O:23])=[CH:6][C:7]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:8][CH:9]=1)([O-:13])=[O:12]

참가 물질

6

반응물 3

HCID 8857Ethyl AcetateHCID 23667635Sodium periodateHCID 86616325Dimethyl-[2-(5-nitro-2-phenoxy-pyridin-4-yl)-vinyl]-amine

생성물 1

HCID 576783284-Formyl-5-nitro-2-phenoxypyridine

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of dimethyl-[2-(5-nitro-2-phenoxy-pyridin-4-yl)-vinyl]-amine (0.2 g, 0.7 mmol) in THF (2 mL) and water (2 mL) was added sodium periodate (0.46 g, 2.1 mmol). The reaction mixture was stirred for 30 min, treated with EtOAc and the solids filtered. The filtrate was washed with sat NaHCO3, dried (Na2SO4), and concentrated to yield 5-nitro-2-phenoxy-pyridine-4-carbaldehyde, the title compound, as a bright yellow solid.

후처리

  1. filtrationthe solids filtered
  2. washThe filtrate was washed with sat NaHCO3
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f0525406590643b490cf3b5057861afd
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531545B2

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