4-Tert-butoxycarbonylamino-4-cyclohexyl-but-2-enoic acid methyl ester → 4-Tert-butoxycarbonylamino-4-cyclohexyl-butyric acid methyl ester

HRID 491870노트

반응식

HRID 491870 반응식
[CH3:1][O:2][C:3](=[O:21])[CH:4]=[CH:5][CH:6]([NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:21])[CH2:4][CH2:5][CH:6]([NH:13][C:14]([O:16][C:17]([CH3:19])([CH3:18])[CH3:20])=[O:15])[CH:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1

참가 물질

4

반응물 1

HCID 670235054-Tert-butoxycarbonylamino-4-cyclohexyl-but-2-enoic acid methyl ester

생성물 1

HCID 670235234-Tert-butoxycarbonylamino-4-cyclohexyl-butyric acid methyl ester

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 4-tert-butoxycarbonylamino-4-cyclohexyl-but-2-enoic acid methyl ester (9 g, 30 mmol) in MeOH (100 mL) was added Pd—C (10% on activated carbon) (1 g) under N2, and the reaction mixture was subjected to hydrogenation under 20 psi for 4 hours. The catalyst was filtered out, and the MeOH was evaporated to yield 4-tert-butoxycarbonylamino-4-cyclohexyl-butyric acid methyl ester as a white solid.

후처리

  1. filtrationThe catalyst was filtered out
  2. customthe MeOH was evaporated

출처 및 근거

ORD 기록
ord-e0b261f5468e4990a47b3b4aa2c64ac7
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531545B2

반응 노트

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