HCID 178454208, 화합물 → HCID 178511821, 화합물

HRID 491879노트

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HRID 491879 반응식
[CH2:1]([O:8][C:9]([C@H:11]1[CH2:16][CH2:15][C@@H:14]([N:17]([CH2:37][CH2:38][O:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[C:18](=[O:36])[CH2:19][CH2:20][C@H:21]([NH:28]C(OC(C)(C)C)=O)[CH:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O>[CH2:1]([O:8][C:9]([C@H:11]1[CH2:16][CH2:15][C@@H:14]([N:17]([C:18](=[O:36])[CH2:19][CH2:20][C@H:21]([NH2:28])[CH:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[CH2:37][CH2:38][O:39][CH2:40][C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 178454208HCID 178454208, 화합물

생성물 1

HCID 178511821HCID 178511821, 화합물

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of 4-{(2-benzyloxy-ethyl)-[4-tert-butoxycarbonylamino-4-(S)-(tetrahydro-pyran-4-yl)-butyryl]-amino}-cis-cyclohexanecarboxylic acid benzyl ester (4.8 g, 7.5 mmol) in TFA (5% in CH2Cl2, 100 mL) was stirred at room temperature overnight. The solvent and most of the TFA was evaporated, and EtOAc (300 mL) was added to the residue. The solution was washed with aq. NaHCO3 and aq. NaCl. The organic layer was dried with MgSO4 and evaporated to yield 4-[[4-amino-4-(S)-(tetrahydro-pyran-4-yl)-butyryl]-(2-benzyloxy-ethyl)-amino]-cis-cyclohexanecarboxylic acid benzyl ester as a light brown oil.

후처리

  1. customThe solvent and most of the TFA was evaporated
  2. additionEtOAc (300 mL) was added to the residue
  3. washThe solution was washed with aq. NaHCO3 and aq. NaCl
  4. dry with materialThe organic layer was dried with MgSO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-eeb12315351c431192f1175cbc824ffb
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531545B2

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