Cyanogen Bromide → HCID 178508229, 화합물

HRID 491882노트

반응식

HRID 491882 반응식
[CH2:1]([O:8][C:9]([C@H:11]1[CH2:16][CH2:15][C@@H:14]([N:17]([C:28](=[O:54])[CH2:29][CH2:30][C@H:31]([NH:38][CH2:39][C:40]2[C:45]([NH2:46])=[CH:44][N:43]=[C:42]([O:47][C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)[CH:41]=2)[CH:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH2:18][CH2:19][O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:56]#[N:57]>CCO>[CH2:1]([O:8][C:9]([C@H:11]1[CH2:12][CH2:13][C@@H:14]([N:17]([C:28](=[O:54])[CH2:29][CH2:30][C@H:31]([N:38]2[CH2:39][C:40]3[CH:41]=[C:42]([O:47][C:48]4[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=4)[N:43]=[CH:44][C:45]=3[N:46]=[C:56]2[NH2:57])[CH:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH2:18][CH2:19][O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:15][CH2:16]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 10476Cyanogen BromideHCID 178508038HCID 178508038, 화합물

생성물 1

HCID 178508229HCID 178508229, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 4-[[4-[(5-amino-2-phenoxy-pyridin-4-ylmethyl)-amino]-4-(S)-(tetrahydro-pyran-4-yl)-butyryl]-(2-benzyloxy-ethyl)-amino]-cis-cyclohexanecarboxylic acid benzyl ester (0.5 g, 0.7 mmol) and BrCN (3M in CH2Cl2, 0.25 mL) in EtOH (20 mL) was stirred at room temperature overnight. The EtOH was evaporated. The resulting oil was stirred in diethyl ether (50 mL) for 30 min. 4-[[4-(2-Amino-6-phenoxy-4H-pyrido[3,4-d]pyrimidin-3-yl)-4-(S)-(tetrahydro-pyran-4-yl)-butyryl]-(2-benzyloxy-ethyl)-amino]-cis-cyclohexanecarboxylic acid benzyl ester was collected as a solid as its corresponding HBr salt.

후처리

  1. customThe EtOH was evaporated
  2. custom4-[[4-(2-Amino-6-phenoxy-4H-pyrido[3,4-d]pyrimidin-3-yl)-4-(S)-(tetrahydro-pyran-4-yl)-butyryl]-(2-benzyloxy-ethyl)-amino]-cis-cyclohexanecarboxylic acid benzyl ester was collected as a solid as its corresponding HBr salt

출처 및 근거

ORD 기록
ord-974faa967ce545c1aefa186647926335
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531545B2

반응 노트

불러오는 중…