3-Oxabicyclo[3.3.1]nonane-2,4-dione → 3-(4-[4-(2-Pyrimidinyl)-1-piperazinyl]-butyl)-3-azabicyclo[3.3.1]nonan-2,4-dione

참여 물질

반응 단계

Following substantially the procedure of Example 1, 2.78 g (11.8 mmol) of 1-(4-aminobutyl)-4-(2-pyrimidinyl) piperazine was reacted with 1.88 g (12.2 mmol) of 3-oxabicyclo[3.3.1]nonan-2,4-dione. The product was chromatographed on silica gel, eluting with dichloromethane/methanol (90:10), to give 2.04 g (47% yield) of the title compound.

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