Ethanol → 2-[(5-Amino-2-phenoxy-pyridin-4-ylmethyl)-amino]-3,N-dimethyl-N-phenethyl-butyramide

HRID 491917노트

반응식

HRID 491917 반응식
[CH3:1][CH:2]([CH3:34])[CH:3]([NH:16][CH2:17][C:18]1[C:23]([N+:24]([O-])=O)=[CH:22][N:21]=[C:20]([O:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:19]=1)[C:4]([N:6]([CH3:15])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5].C(O)C>[Pd].C(OCC)(=O)C>[NH2:24][C:23]1[C:18]([CH2:17][NH:16][CH:3]([CH:2]([CH3:34])[CH3:1])[C:4]([N:6]([CH3:15])[CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:5])=[CH:19][C:20]([O:27][C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)=[N:21][CH:22]=1

참가 물질

5

반응물 2

HCID 702EthanolHCID 670236673,N-Dimethyl-2-[(5-nitro-2-phenoxy-pyridin-4-ylmethyl)-amino]-N-phenethyl-butyramide

생성물 1

HCID 670236882-[(5-Amino-2-phenoxy-pyridin-4-ylmethyl)-amino]-3,N-dimethyl-N-phenethyl-butyramide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 3,N-dimethyl-2-[(5-nitro-2-phenoxy-pyridin-4-ylmethyl)-amino]-N-phenethyl-butyramide (2.1 g, 1.38 mmol), 10% Pd on carbon (2 g), ethanol (75 mL) and ethyl acetate (75 mL) were shaken under a hydrogen atmosphere (50 psi). After 2 hours, the hydrogen was evacuated and the bottle was purged with nitrogen. The resulting mixture was filtered through glass fiber filter paper and the solvent evaporated under low pressure to yield a solid.

후처리

  1. customthe hydrogen was evacuated
  2. customthe bottle was purged with nitrogen
  3. filtrationThe resulting mixture was filtered through glass fiber
  4. filtrationfilter paper
  5. customthe solvent evaporated under low pressure
  6. customto yield a solid

출처 및 근거

ORD 기록
ord-b05a5b80daea44fda9204fffbd105cb7
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531545B2

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