Methylamine → N-methyl-3-nitrobenzamide

HRID 492031

반응식

HRID 492031 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7](O)=[O:8])([O-:3])=[O:2].[CH3:13][NH2:14]>C(Cl)CCl>[CH3:13][NH:14][C:7](=[O:8])[C:6]1[CH:10]=[CH:11][CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 84973-Nitrobenzoic acid

생성물 1

HCID 221964N-methyl-3-nitrobenzamide

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

Commercially available 3-nitrobenzoic acid is reacted with methylamine and EDC under standard conditions to afford N-methyl-3-nitrobenzamide, which is reduced with LAH under standard conditions to afford N-methyl(3-nitrophenyl)methanamine, which is protected with benzylchloroformate under standard conditions to yield t-butyl 3-nitrobenzylmethylcarbamate. This material is nitrosated and reduced to yield t-butyl 3-hydrzazinobenzylmethylcarbamate.

출처 및 근거

ORD 기록
ord-60993d249c19478ba59a7dd508a38856
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531566B2

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