Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylurea → 2-Phenyl-1,2,4-thiadiazolidine-3,5-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylurea | HCID 6145 | — |
| 반응물 | (Chlorothio)formyl chloride | HCID 75990 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Phenyl-1,2,4-thiadiazolidine-3,5-dione | HCID 18449884 | 20% |
반응 단계
To the solution of phenyl-urea (13.0 g, 95.48 mol) in THF (100 mL) was slowly added chlorocarbonyl sulfenylchloride (13 mL, 148.85 mmol) at RT. The reaction mixture was refluxed overnight, the volatiles removed in vacuo yielded 2-phenyl-1,2,4-thiadiazolidine-3,5-dione as a white solid (4.0 g, 20%). 1H NMR (DMSO-d6): δ 12.49 (s, 1H), 7.51 (d, J=8.0 Hz, 2H), 7.43 (t, J=7.6 Hz, 2H), 7.27 (t, J=7.2 Hz, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07531566B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-759bce7b25b84c5180437af1d44f6f5c |
| 출처 메모 | uspto-grants-2009_05 |