1-Hydroxybenzotriazole → {[(6-Benzenesulfonylamino-naphthalen-1-ylmethyl)-carbamoyl]-methyl}-methyl-carbamic acid benzyl ester

HRID 492095

반응식

HRID 492095 반응식
[NH2:1][CH2:2][CH:3]1[CH2:12][CH2:11][CH2:10][C:9]2[CH:8]=[C:7]([NH:13][S:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:16])=[O:15])[CH:6]=[CH:5][C:4]1=2.[CH2:23]([O:30][C:31]([N:33]([CH2:35][C:36](O)=[O:37])[CH3:34])=[O:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.ON1C2C=CC=CC=2N=N1.CC[N+](CCCN(C)C)=C=N>C(Cl)Cl.C(N(CC)CC)C>[CH2:23]([O:30][C:31](=[O:32])[N:33]([CH2:35][C:36](=[O:37])[NH:1][CH2:2][C:3]1[C:4]2[C:9](=[CH:8][C:7]([NH:13][S:14]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)(=[O:16])=[O:15])=[CH:6][CH:5]=2)[CH:10]=[CH:11][CH:12]=1)[CH3:34])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

7

반응물 4

HCID 757711-HydroxybenzotriazoleHCID 97053N-CarbobenzoxysarcosineHCID 218833923-(Dimethylamino)propyl-ethyl-(iminomethylidene)azaniumHCID 57678964N-(5-aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide

생성물 1

HCID 57678985{[(6-Benzenesulfonylamino-naphthalen-1-ylmethyl)-carbamoyl]-methyl}-methyl-carbamic acid benzyl ester

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8471Triethylamine용매

실험 절차

A mixture of N-(5-Aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide, (Benzyloxycarbonyl-methyl-amino)-acetic acid, 1-hydroxybenzotriazole, N-(3-dimethylaminopropyl)-N-ethylcarbodiimide and triethylamine in methylene chloride is stirred at room temperature. The reaction is quenched by addition of water, and the mixture is eluted through silica gel to give {[(6-Benzenesulfonylamino-naphthalen-1-ylmethyl)-carbamoyl]-methyl}-methyl-carbamic acid benzyl ester.

후처리

  1. customThe reaction is quenched by addition of water
  2. washthe mixture is eluted through silica gel

출처 및 근거

ORD 기록
ord-4366e0d83b2f484e97dba99d5a6ef4ff
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531577B2

연결된 노트

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