Ethyl trifluoroacetate → 2,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide

HRID 492117노트

반응식

HRID 492117 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][NH2:8])[CH2:2]1.C([O:11][C:12](=O)[C:13]([F:16])([F:15])[F:14])C>CO>[F:14][C:13]([F:16])([F:15])[C:12]([NH:8][CH2:7][CH:3]1[O:4][CH2:5][CH2:6][NH:1][CH2:2]1)=[O:11]

참가 물질

4

반응물 2

HCID 9794Ethyl trifluoroacetateHCID 45420271-(Morpholin-2-yl)methanamine

생성물 1

HCID 115502612,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
22 °C

실험 절차

To a stirred solution of morpholin-2-ylmethylamine (3.1 g) in methanol (70 ml) under nitrogen was added an ethereal solution of ethyl-α,α,α-trifluoroacetate (5 ml in 20 ml ether) which had been washed with saturated aqueous sodium bicarbonate, water and brine, and dried. The mixture was stirred for 30 min at 22° C. before removal of all volatiles in vacuo. The residue was dissolved in methanol (10 ml) and the volatiles again removed in vacuo to give the title compound as a white crunchy foam (4.9 g).

후처리

  1. washhad been washed with saturated aqueous sodium bicarbonate, water and brine
  2. customdried
  3. dissolutionThe residue was dissolved in methanol (10 ml)
  4. customthe volatiles again removed in vacuo

출처 및 근거

ORD 기록
ord-845b7cb7666c41b9af897208a284404b
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531651B2

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