Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-(4,6-Dimethoxypyrimidine-2-yl)-2-methyl-7-metoxymethylindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 1-(4,6-Dimethoxypyrimidin-2-yl)propan-2-one | HCID 11264052 | — |
| 반응물 | 2-Methoxymethylphenylhydrazine | HCID 12979365 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-(4,6-Dimethoxypyrimidine-2-yl)-2-methyl-7-metoxymethylindole | HCID 11573215 | 46.2% |
반응 단계
Into a reactor were fed 6.2 g (31.6 m moles) of 1-(4,6-dimethoxypyrimidine-2-yl)-2-propanone, 4.8 g (31.5 m moles) of 2-methoxymethylphenylhydrazine, 4.76 g (34.9 m moles) of zinc chloride and 60 ml of toluene. Refluxing was made for 2 hours with heating. After the completion of the reaction, the reaction mixture was cooled to room temperature. Water and ethyl acetate were added and phase separation was made. The ethyl acetate layer was concentrated. The resulting crystals were washed with diisopropyl ether to obtain 4.57 g (14.6 m moles) of 3-(4,6-dimethoxypyrimidine-2-yl)-2-methyl-7-metoxymethylindole. Yield: 46%
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07531654B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-9cf255d73db140c78ebbe8553dcd104d |
| 출처 메모 | uspto-grants-2009_05 |