Thionyl Chloride → HCID 86596403, 화합물
반응식
S(Cl)([Cl:3])=O.[C:5]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH3:17])[CH:15]=2)[N:10]([C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]=[CH:20][N:19]=2)[CH:9]=1)(O)=[O:6]>>[ClH:3].[Cl:3][C:5]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH3:17])[CH:15]=2)[N:10]([C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]=[CH:20][N:19]=2)[CH:9]=1)=[O:6]참가 물질
3
실험 절차
15 cm3 of thionyl chloride are added at 20° C. under an argon atmosphere to 1.27 g (3.75 mmol) of 3-carboxy-1-(isoquinol-1-yl)-5-methyl-1H-indole. After stirring at reflux for 4 hours, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa), successively triturated twice with 10 cm3 of dimethoxyethane and then concentrated to dryness under reduced pressure (2.7 kPa) to give 1.2 g of 3-chlorocarbonyl-1-(isoquinol-1-yl)-5-methyl-1H-indole hydrochloride in the form of a yellow solid which is used directly in the following step.
후처리
- temperatureat reflux for 4 hours
- concentrationthe reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa)
- customsuccessively triturated twice with 10 cm3 of dimethoxyethane