반응식
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]([F:12])[C:3]=1C(O)=O.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:20])C=CC=CC=1.[C:30]([NH:34][S:35]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1[C:44]1[CH:49]=[CH:48][C:47]([CH2:50][NH:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58])=[CH:46][CH:45]=1)(=[O:37])=[O:36])([CH3:33])([CH3:32])[CH3:31].C([N:61]([CH2:64]C)CC)C>>[C:30]([NH:34][S:35]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1[C:44]1[CH:49]=[CH:48][C:47]([CH2:50][N:51]([CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58])[C:64](=[O:20])[NH:61][C:3]2[C:7]([F:12])=[CH:8][C:9]([F:11])=[CH:10][C:2]=2[F:1])=[CH:46][CH:45]=1)(=[O:37])=[O:36])([CH3:33])([CH3:32])[CH3:31]참가 물질
5
반응물 4
생성물 1
실험 절차
Using 2,4,6-trifluorobenzoic acid (0.27 g), diphenylphosphoryl azide (0.44 g), triethylamine (0.17 g) and N-[[2′-[(t-butylamino)sulfonyl]-1,1′-biphenyl-4-yl]methyl]-N-heptylamine (0.43 g), N′-[[2′-[(t-butylamino)sulfonyl]-1,1′-biphenyl-4-yl]methyl]-N′-heptyl-N-(2,4,6-trifluorophenyl)urea was afforded as colorless crystals (0.49 g) by a similar procedure as in Example 4. Yield: 81%.
출처 및 근거
- ORD 기록
- ord-93713c4e2de840a385d60127aa87377e
- 출처 데이터셋
- uspto-grants-2009_05
- 특허 번호
- US07531576B2
연결된 노트
불러오는 중…