2-{[4-(1-Methylpiperazin-4-yl)piperidin-1-yl]carbonylamino}-4-(4-nitrophenoxy)pyridine → 4-(4-Aminophenoxy)-2-{[4-(1-methylpiperazin-4-yl)piperidin-1-yl]carbonylamino}pyridine

HRID 492892노트

반응식

HRID 492892 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([NH:16][C:17]3[CH:22]=[C:21]([O:23][C:24]4[CH:29]=[CH:28][C:27]([N+:30]([O-])=O)=[CH:26][CH:25]=4)[CH:20]=[CH:19][N:18]=3)=[O:15])[CH2:10][CH2:9]2)[CH2:4][CH2:3]1>O1CCCC1.[OH-].[Pd+2].[OH-].[C]>[NH2:30][C:27]1[CH:26]=[CH:25][C:24]([O:23][C:21]2[CH:20]=[CH:19][N:18]=[C:17]([NH:16][C:14]([N:11]3[CH2:10][CH2:9][CH:8]([N:5]4[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]4)[CH2:13][CH2:12]3)=[O:15])[CH:22]=2)=[CH:29][CH:28]=1

참가 물질

4

반응물 1

HCID 231531552-{[4-(1-Methylpiperazin-4-yl)piperidin-1-yl]carbonylamino}-4-(4-nitrophenoxy)pyridine

생성물 1

HCID 231533634-(4-Aminophenoxy)-2-{[4-(1-methylpiperazin-4-yl)piperidin-1-yl]carbonylamino}pyridine수율 98.1%

시약·촉매·용매 2

HCID 178502593HCID 178502593, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

2-{[4-(1-Methylpiperazin-4-yl)piperidin-1-yl]carbonylamino}-4-(4-nitrophenoxy)pyridine (163 mg) was dissolved in tetrahydrofuran (20 ml). After adding 20% palladium hydroxide-carbon (104 mg), the mixture was stirred overnight under a hydrogen atmosphere. The catalyst was filtered and washed with tetrahydrofuran. The filtrate and the washings were combined and concentrated under reduced pressure, and the resultant residue was dried under reduced pressure to provide the title compound (149 mg, 98%) as pale yellow powder.

후처리

  1. filtrationThe catalyst was filtered
  2. washwashed with tetrahydrofuran
  3. concentrationconcentrated under reduced pressure
  4. dry with materialthe resultant residue was dried under reduced pressure

출처 및 근거

ORD 기록
ord-a7cae0d2447544969bf7806c78576e15
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531532B2

반응 노트

불러오는 중…