4-(Dimethylamino)Benzaldehyde → (4E)-2-(1,3-benzothiazol-2-yl)-4-{[4-(dimethylamino)phenyl]-methylidene}-5-methyl-2,4-dihydro-3H-pyrazol-3-one

HRID 493010

반응식

HRID 493010 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[N:10]1[C:14](=[O:15])[CH2:13][C:12]([CH3:16])=[N:11]1.[CH3:17][N:18]([CH3:27])[C:19]1[CH:26]=[CH:25][C:22]([CH:23]=O)=[CH:21][CH:20]=1.N1CCCCC1>C(O)C.O>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[N:10]1[C:14](=[O:15])/[C:13](=[CH:23]/[C:22]2[CH:25]=[CH:26][C:19]([N:18]([CH3:27])[CH3:17])=[CH:20][CH:21]=2)/[C:12]([CH3:16])=[N:11]1

참가 물질

6

반응물 3

HCID 74794-(Dimethylamino)BenzaldehydeHCID 8082PiperidineHCID 459449Pyrazol-5(4H)-one, 1-(2-benzothiazolyl)-3-methyl-

생성물 1

HCID 57679781(4E)-2-(1,3-benzothiazol-2-yl)-4-{[4-(dimethylamino)phenyl]-methylidene}-5-methyl-2,4-dihydro-3H-pyrazol-3-one

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

1 g (4.32 mmol) of 2-(1,3-benzothiazol-2-yl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one and 1.93 g (12.96 mmol) of 4-(dimethylamino)benzaldehyde are stirred under reflux with the addition of 3 ml of piperidine in absolute ethanol for 2 hours. The mixture is then diluted with water and the bright red precipitate is filtered off, then washed with water and a small amount of cold methanol and dried under reduced pressure.

후처리

  1. filtrationthe bright red precipitate is filtered off
  2. washwashed with water
  3. dry with materiala small amount of cold methanol and dried under reduced pressure

출처 및 근거

ORD 기록
ord-97853ff632404409a3f0993a6fe48090
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534273B2

연결된 노트

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