Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Vanillin → (4E)-2-(1,3-benzothiazol-2-yl)-4-{[4-hydroxy-3-(methyloxy)phenyl]-methylidene}-5-methyl-2,4-dihydro-3H-pyrazol-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Vanillin | HCID 1183 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Pyrazol-5(4H)-one, 1-(2-benzothiazolyl)-3-methyl- | HCID 459449 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (4E)-2-(1,3-benzothiazol-2-yl)-4-{[4-hydroxy-3-(methyloxy)phenyl]-methylidene}-5-methyl-2,4-dihydro-3H-pyrazol-3-one | HCID 136385044 | — |
반응 단계
1 g (4.32 mmol) of 2-(1,3-benzothiazol-2-yl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one and 1.97 g (12.96 mmol) of 4-hydroxy-3-methoxybenzaldehyde are stirred under reflux with the addition of 3 ml of piperidine in absolute ethanol for 2 hours. The mixture is then diluted with water and the orange-yellow precipitate is filtered off, then washed with water and a small amount of cold methanol and dried under reduced pressure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07534273B2 |
| 출처 데이터셋 | uspto-grants-2009_05 |
| ORD ID | ord-05cff674b3534b0793ca50617ff8a74e |
| 출처 메모 | uspto-grants-2009_05 |